Thermo Fisher Scientific Q Exactive Hybrid Quadrupole-Orbitrap Mass Spectrometer

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The Thermo Fisher Scientific Q Exactive Hybrid Quadrupole-Orbitrap Mass Spectrometer is a versatile benchtop LC-MS/MS system designed for rapid identification, quantification, and confirmation of compounds. 

Combining quadruple precursor ion selection with high-resolution, accurate-mass (HRAM) Orbitrap detection, it excels in both untargeted and targeted screening. This mass spectrometer is ideal for applications in drug discovery, proteomics, environmental and food safety, clinical research, and forensic toxicology.

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Question & Answers For:

Thermo Fisher Scientific Q Exactive Hybrid Quadrupole-Orbitrap Mass Spectrometer

Past Questions, Helpful Answers.

q.

What type of samples can this mass spectrometer analyze?

a.

This mass spectrometer is suitable for a wide range of samples, including biological fluids, environmental samples, food matrices, pharmaceuticals, and forensic specimens. It is highly effective for both small and large molecules in complex mixtures.

q.

How does this system improve compound identification?

a.

It combines quadrupole precursor ion selection with high-resolution, accurate-mass (HRAM) Orbitrap detection, providing precise mass measurements and high spectral quality for both known and unknown compounds.

q.

Is this system capable of both qualitative and quantitative analysis?

a.

Yes, the Q Exactive system supports both qualitative and quantitative workflows, making it ideal for untargeted and targeted screening, structural elucidation, and biomarker discovery.

q.

What resolution and mass accuracy does this system offer?

a.

It provides high-resolution capabilities, often exceeding 140,000 FWHM, with mass accuracy typically below 1 ppm, ensuring precise and reproducible results.

q.

Can this instrument be used for proteomics applications?

a.

Yes, it is widely used in proteomics for protein identification, post-translational modification analysis, and peptide quantification due to its high resolution and sensitivity.

q.

How does this system handle complex mixtures?

a.

The Orbitrap technology allows for high-resolution detection and superior mass accuracy, making it effective in analyzing complex mixtures such as biological samples and environmental extracts.

q.

What type of ionization sources are compatible with this system?

a.

It supports electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI), making it versatile for various applications.

 

q.

Does this mass spectrometer support high-throughput analysis?

a.

Yes, it is designed for rapid sample processing, making it suitable for high-throughput workflows in drug discovery, food safety, and clinical research.

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